Evaluation of the Involvement of Heme Oxygenase-1 Expression in Discoid Lupus Erythematosus Lesions

Discoid lupus erythematosus (DLE) is a chronic autoimmune disease that primarily affects the skin, causing red, scaly patches may be disfiguring and can cause permanent scarring. This study aimed to investigate potential clinical therapeutic applications of heme oxygenase-1 (HMOX1) in context DLE. Immunohistochemical staining bioinformatics analysis were performed on skin biopsy samples from DLE patients examine levels HMOX1 correlate with markers inflammation. Our revealed negative correlation between inflammatory status lesions, as well an inverse infiltration M1 macrophages activated mastocytes. These findings suggest plays crucial role regulation inflammation could target biomarker for